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Thermal and photochemical electron-transfer studies of chromium, cobalt and ruthenium-polymer and -surfactant complexes, Reactions of metal complexes in micelles and in micro-emulsions. Synthesis of some novel metal-surfactant/polymer complexes and their biological activities. Polymer-metal complex-DNA interactions, Surfactant-metal complex-DNA interactions. All these studies are being carried out making use of instruments like spectrophotometers, spectrofluorometers, laser-flash photolysis apparatus, nanosecond single-photon counting instruments for lifetime measurements, Gel-Chromatography etc. | |||
| In the above areas we have achieved the following: | ||||
| Our studies on steady and flash photolysis studies on the charge transfer photochemistry of many polymer anchored as well as surfactant-cobalt(III) amine complexes have cleared some uncertainties in the general mechanism of charge-transfer photoreduction of cobalt(III)-amine complexes. Flash photolysis studies on these complexes revealed the nature of the intermediate radicals through which we have identified the type of charge-transfer responsible for the photoreduction. | ||||
| We have measured the critical micelle concentration values (CMC) of these complexes by conductivity methods. The CMC values of all these surfactant complexes are almost 100 fold lower compared to those for the other well-known organic surfactants like sodium dodecylsulphate and cetyltrimethylammonium bromide. These surfactant complexes have high anthelmintic properties. Also we have investigated the thermodynamics of micelle formation of surfactant-metal complexes. | ||||
| Emission and life-time quenching studies were done using the above mentioned metal surfactant complexes as quenchers and Ru(bpy)32+ or Ru(phen)32+ as the sesitizer in self micelles formed by the surfactant complexes using nanosecond laser flash photolysis instruments. | ||||
| Both inner-sphere and outer-sphere electron transfer reactions involving surfactant cobalt(III) and chromium(III) complexes in micelles, in cyclodextrin media and in DNA are being routinely studied. Photochemical studies are also being undertaken in these media. | ||||
| The interaction pattern of nucleic acids with our surfactant and polymer-metal complexes have been actively pursued. | ||||
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Antimicrobial and antitumor properties of some of our surfactant and polymer-metal complexes are also being checked. |
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Selected Publications |
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| 1 |
R. Senthil Kumar, S. Arunachalam, V.S. Periasamy, C.P. Paul, A. Riyasdeen, and M.A. Akbarsha, "DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes", Eur. J. Med. Chem.(In press).Doi:10.1016/j.ejmech.2007.09.017 |
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| 2 | R. Senthil Kumar, S. Arunachalam, V.S. Periasamy, C.P. Paul, A. Riyasdeen, and M.A. Akbarsha,"Synthesis, DNA binding and antitumor activities of some novel polymer-cobalt(III) complexes containing 1,10-phenanthroline ligand", Polyhedron 27, 1111 (2008) | |
| 3 | R. Senthil Kumar, K. Sasikala and S. Arunachalam,"DNA interaction of some polymer-copper(II) complexes containing 2,2'-bipyridyl ligand and their antimicrobial activities", J. Inorg. Biochem 102, 234 (2008). | |
| 4 |
R. Senthil Kumar, K. Sasikala and S. Arunachalam, "Luminescence quenching of Ru(phen)32+ by some polymer-cobalt(III) complexes- Effect of micelles and DNA", J. Chem. Sci. 119, 231 (2007). |
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| 5 | R. Senthil Kumar and S.Arunachalam, "DNA binding and antimicrobial studies of some polyethyleneimine-copper(II) complex samples containing 1,10-phenanthroline and L-theronine as co-ligands", Polyhedron 26, 3252 (2007) . | |
| 6 |
N. Kumaraguru, K. Santhakumar, S. Arunachalam, M.N. Arumugham, "Thermodynamics and Micellar Properties of Some Surface Active Cobalt(III) Metallosurfactants in Nonaqueous Medium", Int. J. Chem. Kinet 39, 22 (2007). |
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| 7 |
N. Kumaraguru, S. Arunachalam, M.N. Arumugam and K.Santhakumar,"Metallosurfactants of chromium(III) coordination complexes.Synthesis,characterization and determination of CMC values" , Transition Metal Chemistry 31,250 (2006). |
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| 8 | M.N.Arumugam and S.Arunachalam, "Synthesis,characterization and spectra of some neutral amphipathic cobaloxime complexes", Indian J.Chem. 36A,315 (1997). | |
| 9 | S.Arunachalam and P.Natarajan, "Photochemistry of macromolecular-bound-cobalt(III) amine complexes", J.Chem.Soc. Chem.Commun.(London),472(1983). | |
| 10 |
A.D.Kirk, S.Arunachalam and D.Kneeland, "Photoaquation of the iodopentamminechromium(III) ion in acidic aqueous solution", Inorg.Chem. 25, 3551 (1986). |
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| Book | ||
| S.Arunachalam, "Inorganic Photochemistry - An Introduction to Photochemical and Photophysical Aspects of Metal Complexes", Kala Publications, Tiruchirappalli, India (2002). | ||
| Funded Research Projects Handled/On Going | ||
| 1 | "Micellar effect on the reactions of some cobalt(III) and chromium(III) coordination compounds" - Funded by University Grants Commission, India(1988-1990). | |
| 2 | "Experimental and theoretical studies on some oxidations involving aromatic and heterocyclic compounds" - Funded by University Grants Commission, India(1989-1992). (in collaboration with another Professor in the department) | |
| 3 | "Kinetics of aquation of some micelle formable cobalt(III) and chromium(III) amine surfactant complexes" - Funded by University Grants Commission, India(1994-1995). | |
| 4 | "Micellar effect on the photochemistry of some surfactant cobalt(III) complexes" - Funded by University Grants Commission, India (1996-1997). | |
| 5 | "Hydrophobic effect on the electrochemical and photochemical behaviour of some micelle formable cobalt(III) amine surfactant complexes" - Funded by Council of Scientific and Industrial Research, Government of India(1996-1999). | |
| 6 | "Kinetics of aquation of a surfactant chromium(III) complex and its ordinary analogue" - Funded by University Grants Commission, India(1999-2000). | |
| 7 | "Kinetic studies on the aquation and electron transfer reactions of some cobalt(III) and chromium(III) surfactant complexes in micellar and b-cyclodextrin media" - Funded by University Grants Commission, India(2001-2004). | |
| 8 | "Studies on Outer-Sphere Electron Transfer Between some Surfactant-Cobalt(III) complexes and Fe2+/Fe(CN)64- in Micelles and in DNA"- Funded by Council of Scientific and Industrial Research, Government of India(2006-2009). | |
| 9 | "Studies on Photosensitized Electron Transfer Between some Ruthenium-Polypyridine complexes and Surfactant-Cobalt(III)-Amine Complexes in Micelles, Reverse Micelles and in DNA"- Funded by University Grants Commission, India(2007-2010). | |
| Scientific Visits Abroad | ||
| 1 | Canada | |
| 2 | USA | |
| 3 | Japan | |
| 4 | Germany | |
| 5 | Spain | |
| Papers presented in Conferences, etc: | ||
| About 20 papers have been presented in conferences, etc. | ||
| Courses Given to College & University Teachers: | ||
| Acted as resource person in several courses like UGC-Sponsored Orientation and Refresher courses Conducted by Academic Staff Colleges for College and University Teachers. | ||
| Special Status | ||
| Acted as Syndicate Member (Policy making and executive body) of the Bharathidasan University during 1991-'94 | ||