| Dr. S. Muthusamy | |
Specialization: Synthetic Organic Chemistry.Area(s) of Research Work: Chemistry of rhodium carbenoids; Development of tandem reactions, stereoselective reactions and new synthetic methods; Synthesis of biologically interesting complex new molecules, macrocycles and supramolecular chemistry.
|
|
|
Professor
Department of Chemistry, Bharathidasan University, Tiruchirappalli - 620 024, INDIA |
Rese
 |
||
|
The rapid generation of molecular complexity, in a controlled and predictable manner, is a contemporary theme in the practice of modern organic synthesis. This process finds application in accessing newer entities for the pharmaceutical industry. Many interesting regio-, chemo- and diastereoselective reactions, Transition metal catalyzed tandem reactions and Synthesis of functionalized new complex carbocycles as well as heterocycles with an atom economy were achieved via Rhodium Carbenoid Chemistry. |
||
Selected
Publications:
| 1 | Muthusamy, S.; Gnanaprakasam, B.; Surehsh, E. “Desymmetrization of cyclic anhydrides using dihydroxy compounds: Selective synthesis of macrocyclic tetralactones” Org. Lett. 2006, 8, 1913. | |
| 2 | Muthusamy, S.; Gnanaprakasam, B.; Surehsh, E. "Regioselective nucleophilic addition to carbonyl ylide intermediates: A novel diastereoselective synthesis of cycloalkyl fused furan-3-ones" Org. Lett. 2005, 7, 4577. | |
| 3 | Muthusamy, S.; Krishnamurthi, J.; Nethaji, M. “Highly regio-, chemo- and diastereoselective synthesis of oxa-bridged spirocycles: A novel observation of reverse selectivity” J. Chem. Soc., Chem. Commun. 2005, 3862. | |
| 4 | Muthusamy, S.; Srinivasan, P. “Facile chemoselective rhodium carbenoid N-H insertion reactions: Synthesis of 3-arylamino- or 3-heteroarylpiperidin-2-ones” Tetrahedron Lett. 2005, 46, 1063. | |
| 5 | Muthusamy, S.; Gnanaprakasam, B. “Imidazolium salts as phase transfer catalysts for the dialkylation and cycloalkylation of active methylene compounds” Tetrahedron Lett. 2005, 46, 635. | |
| 6 | Muthusamy, S.; Gunanathan, C.; Nethaji, M. “Multicomponent Reactions of Diazoamides: Diastereoselective synthesis of mono- and bis-spirofuro-oxindoles” J. Org. Chem. 2004, 69, 5631. | |
| 7 | Muthusamy, S.; Gunanathan, C.; Nethaji, M. “Stereoselective epoxide generation with cyclic rhodium carbenoids: A new access to spiro-indolooxiranes” Synlett 2004, 639. | |
| 8 | Muthusamy, S.; Gunanathan, C. “Rh2(OAc)4 Catalyzed reactions of diazoimides: a simple and novel synthesis of 2,3-fused perhydrooxazolones and bis(perhydrooxazolones)” J. Chem. Soc., Chem. Commun. 2003, 440. | |
| 9 | Muthusamy, S.; Babu, S. A.; Gunanathan, C.; Ganguly, B.; Suresh, E.; Dastidar, P. “Tandem cyclization-cycloaddition of rhodium carbenoids: Stereoselective synthesis of epoxy-bridged tetrahydropyranone ring systems” J. Org. Chem. 2002, 67, 8019. | |
| 10 | Muthusamy, S.; Gunanathan, C.; Babu, S. A.; Suresh, E.; Dastidar, P. “First example of regiospecific intermolecular C-H insertion reactions of cyclic rhodium carbenoids: Novel synthesis of 3,3'-indolyloxindoles” J. Chem. Soc., Chem. Commun. 2002, 824. |
Honours and Awards
1. Chemical Research Society of India; Bronze Medal – 2006
2. Alexander von Humboldt Fellowship, Germany - Reinvitation Program - 2004
3. Prof. D. K. Banerjee Memorial Lecture Award, IISc, Bangalore – 2003
4. INSA-Royal Society Exchange Visiting Fellowship, Aug. - Dec. 2001
5. CSIR Young Scientist Award in Chemical Sciences – 1998
6. Alexander von Humboldt Fellowship, Germany - 1993
Abroad Visit
1. Germany
2. United Kingdom
For more information please visit: www.geocities.com/muthuchem
 |