Dr. Shanmugam Narkunaraja Ph.D.,
Associate Professor, Department of Bio-Medical Science
Education
Ph. D. in Biochemistry, IISc, Bangalore, India.
M. Sc. in Medical Biochemistry, JIPMER, Puducherry, India.
Professional Experience
2001 - 2008 : Senior Research Fellow, Dept of Diabetes, Beckman Research Institute of City of Hope, California, USA.
1999 - 2001 : Post-doctoral Associate, Dept of Cell and Neurobiology, Rutgers University, NJ, USA.
1997 - 1999 : Post-doctoral Fellow, Institute of Molecular Biology, Academia Sinica Taiwan.
Area of Specialization
Diabetes and Cardiovascular Diseases
Membership in Professional Societies
American Heart Association Member (2001 - Present)
Society of Biological Chemist of India (SBC) Member (1986-1997)
Honors/Awards
2008 JBC article was selected as “Papers of the Week” “Author Profile”
1993-96 Senior Research Fellowship from Indian UGC
1990-92 Junior Research Fellowship from Indian UGC
1986-89 Best Post-graduate Alumnus Award JIPMER
1986-89 Rameshwardasji Birla Smarath Kosh Fellowship, Bombay
Editorial Actitivity (2007-2008)
1. Blood (International journal Published from American Society of Hematology)
2. Journal of Immunology. (International journal Published from The American Association of
Immunologist Inc)
Major Research Interests
Cellular and Molecular Mechanisms of accelerated cardiovascular disease in diabetes. Mechanisms of hyperglycemia- and oxidant stress-induced gene regulation. Genomics, Proteomics and MicroRNAs.
Regulation of transcription factors, and inflammatory genes related to cardiovascular and diabetic complications. Promoter analyses, Co-activators, Co-repressors. Post-translational regulation (mRNA stability).
Mechanisms of hyperglycemia- and oxidant stress-induced, RNA modifications and cellular dysfunction in Leukocytes, and Islets.
Signal transduction mechanisms of action of cytokines, lipids and oxidant stress, particularly in Leukocytes.
Mechanisms of cell adhesion. Leukocyte-Vascular interactions. Intercellular interactions in the vessel wall.
Lectures
1. Experimental Biology, San Diego, CA, USA, 2008.
2. American Diabetes Association, 65th Scientific Sessions, SanDiego, CA, USA, 2005.
3. American Society of Nephrology, 37th Annual Meeting St. Lous, MO, USA 2004.
4. American Diabetes Association, 63rd Scientific Sessions, New Orleans, LA, USA 2003.
National and International Meetings attended: Twenty Six (26)
Publications
1. Shanmugam N, Reddy MA, and Natarajan R. Distinct Roles of Heterogeneous Nuclear Ribonuclear Protein K and microRNA-16 in Cyclooxygenase-2 RNA Stability Induced by S100b, a Ligand of the Receptor for Advanced Glycation End Products. J.Biol. Chem 2008 283(52):36221-33.
2. Li Y, Reddy MA, Miao F, Shanmugam N, ,Yee JK, Hawkins D, Ren B and, Natarajan R. Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation. J.Biol Chem, 2008 283(39):26771-81.
3. Figarola JL, Loera S, Weng Y, Shanmugam, N, Natarajan R and Rahbar S. LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat. Diabetologia 51:882-91, 2008.
4. Xu ZG, Yuan H, Lanting L, Li SL, Wang M, Shanmugam N, Kato M, Adler SG, Reddy MA and Natarajan R. Products of 12/15-lipoxygenase upregulate the angiotensin II receptor. J Am Soc Nephrol 19(3):559-69. 2008.
5. Figarola JL, Shanmugam N, Natarajan R and Rahbar S. Anti-inflammatory effects of the AGE inhibitor LR-90 in human monocytes. Diabetes, 56:647-55. 2007.
6. Shanmugam N, Ransohoff RM and Natarajan, R. Interferon-γ-inducible Protein (IP)-10 mRNA Stabilized by RNA-binding Proteins in Monocytes Treated with S100b. J. Biol. Chem 281:31212- 21, 2006.
7. Shanmugam N, Figarola JL, Li Y, Swiderski PM, Rahbar S and Natarajan R. Proinflammatory effects of advanced lipoxidation end products in monocytes. Diabetes..57:879-88,2008.
8. Xu ZG, Li S-L, Lanting L, Kim YS, Shanmugam N, Reddy MA, and Natarajan R. Relationship between 12/15-Lipoxygenase and Cyclooxygenase-2 in Mesangial Cells: Potential Role in Diabetic Nephropathy. Kidney Internationals. 69, 512–519, 2006.
9. Shanmugam N, Todorov IT, Nair I, Omori K, Reddy MA and Natarajan R. Increased expression of Cyclooxygenase-2 in Human Pancreatic Islets treated with high glucose or ligands of RAGE, and in islets from diabetic mice. Diabetologia.49: 100–107, 2006.
10. Shanmugam N, Gonzalo IT, and Natarajan R. Molecular mechanisms of High Glucose-Induced Cyclooxygenase-2 Expression in Monocytes. Diabetes. 53:795-802, 2004.
11. Shanmugam N, Kim YS, Landing L and Natarajan R. Regulation of Cyclooxygenase-2 Expression in Monocytes by Ligation of the Receptor for Advanced Glycation End Products (RAGE), J. Biol. Chem.278: 34834-34844, 2003.
12. Shanmugam N, Reddy MA, Guha M, and Natarajan R. High glucose induces the expression of proinflammatory cytokine and chemokine mRNAs in monocytic cells - a gene array analysis. Diabetes, 52: 1256-64, 2003.
13. Tumaney AW, Shanmugam N, and Ram R. Identification of lysophophatidic acid acyltranferase in microsomal membrane of developing castor endosperm. Current Science 76: 660-664, 1999.
14. Shanmugam N, Antony K and Jayabaskaran C. Changes in aminoacylation levels of plastid tRNA species in dark-grown ragi (Eleucine coracana) seedlings treated with phytohormones and light Journal of Plant Physiology. 151:450-456, 1997.
15. Shanmugam N, Antony K and Jayabaskaran C. Effects of exogenous phytohormones on plastid tRNA modifications in ragi coleoptiles Indian J Biochem Biophys. 34(6):494-500, 1997
Research Scholars
Gobinath Shanmugam
Somasundaram Raghavan
Contact Information
Department of Bio-Medical Science,
School of Basic Medical Sciences,
Bharathidasan University, Tiruchirappalli – 620 024.
E-mail: nshanmugam@bdu.ac.in, snarkunaraja@gmail.com
Mobile: +91- 9942884143.