Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

Dr. S. Muthusamy

Dr. S. Muthusamy

School of Chemistry

Personal Page:
Fax: +91 431 2407045


Postdoctoral Research, 1992-1995, Technical University and Ruhr University, Germany.

Ph.D. in Organic Chemistry, 1991, Dept. of Organic Chemistry, University of Madras, Chennai

Professional Experience

Professor, Department of Chemistry, Bharathidasan University, Tiruchirappalli (2006-till date).

Scientist, Central Salt and Marine Chemicals Research Institute (CSMCRI), Gujarat (1997-2006).

CSIR, SRA, School of Chemistry, University of Hyderabad, Hyderabad (1995-1997).

Guest Scientist in Ruhr University, Bochum, Germany (1994-1995).

Guest Scientist in Technical University, Braunschweig, Germany (1993-1994).

Lecturer, Department of Organic Chemistry, University of Madras, Chennai (1992-1993).

Research Associate, Department of Organic Chemistry, University of Madras, Chennai (1991-1992).

Research Interests

• Green chemistry

• Metathesis reactions

• Chemistry of 1,3-dipoles

• Chemistry of diazocarbonyl compounds

• Transition metal catalyzed tandem reactions

• Synthesis of macrocycles and supramolecular chemistry

• Synthesis towards natural molecules via rhodium carbenoids

• Stereoselective synthesis and development of new methodologies

• Synthesis of biologically interesting carbocyclic and heterocyclic molecules

Visits Abroad

Feb. 2009 - May 2009: University of Manchester Honorary Fellow, UK under INSA-Royal Society Exchange Program.

Aug. 2004 - Oct. 2004: Visiting Scientist, Germany under Alexander von Humboldt Re-invitation program.

Sept. 2001 - Nov. 2001: Exeter University Honorary Fellow, UK under INSA-Royal Society Exchange Program.

May 1993 - Mar. 1995: Guest Scientist in Technical University, Braunschweig and Ruhr University, Bochum, Germany.

Honours, Awards and Memberships

2011-2014: Council Member, National Organic Symposium Trust (NOST), India.

2009: 76th Indian Science Congress-Madurai Kamaraj University Eminent Scientist Award, Madurai.

2009: Prestigious Royal Society-INSA exchange visiting fellowship, University of Manchester, UK.

2006: Bronze Medal lecture award, Chemical Research Society of India (CRSI), India.

2003: Prof. D. K. Banerjee Memorial Lecture Award, IISc, Bangalore.

2001: Prestigious Royal Society-INSA exchange visiting fellowship – University of Exeter, UK.

2000: Life Membership in Chemical Research Society of India, India.

1998: CSIR Young Scientist Award in Chemical Sciences, CSIR, New Delhi.

1995: CSIR Senior Research Associate, CSIR, New Delhi.

1993: Prestigious Alexander von Humboldt Fellowship, Germany.

1988: CSIR-UGC National Eligibility Test (NET), CSIR, New Delhi.

Research Guidance

Ph. D. 05 (Completed), 08 (ongoing)

M.Phil.,02 (Completed), 02 (ongoing)

M.Sc., 11 (Completed), 01 (ongoing)

Project Grants Received

S. No.

Title of the Project

Funding Agency

Year of completion

Amount in Lakhs (Rs)


Studies on transition metal catalyzed reactions of a-diazo ketones.





Studies on transition metal catalyzed reactions of a-diazo ketones towards the synthesis of pharmaceutically important molecules.





Studies on carbonyl ylides towards the synthesis of terpenoid and alkaloid systems.





Studies on the transition metal catalyzed route to the synthesis of macrocyclic compounds and its supramolecular chemistry





Equipment donation grant for FT-Infrared Spectrometer



Euro 15,000


Studies on synthesis of valuable chemicals via an environment friendly route using ionic liquids and enzymes






Studies on the synthesis of steroids from diazocarbonyl compounds using transition metal complexes as catalyst





MoU signed with E. I. du Pont de Nemours and Company, USA



US$ 10,000


Studies on the synthesis of macrocyclic lactones and lactams via ring closing metathesis reaction





Studies on the rhodium carbenoids towards the synthesis of spiro-heterocycles, indole alkaloids and their asymmetric reactions




Workshops / Symposia / Conferences / Courses Organized

1. Coordinator: Refresher course on “Frontiers in Chemistry-2010” for university/college teachers during 6th Oct. to 26th Oct. 2010.

2. Convener: National Conference on “Recent Trends in Organic Synthesis-2011” (RTOS-2011) in Hotel SRM, Tiruchirappalli on the occasion of UGC-SAP program of the School of Chemistry and International Year of Chemistry during 24-26th Feb. 2011.

Research Papers in Books / Monographs / Reviews

Book Chapters

1. Block, K.; Kappert, W.; Kirschfeld, A.; Muthusamy, S.; Schroeder, K.; Sander, W.; Kraka, E.; Sosa, C.; Cremer, D.
Carbonyl O-oxides and Dioxiranes – From Laboratory Curiosities to Useful Reagents
Peroxide Chemistry, Mechanistic and Preparative Aspects of Oxygen Transfer
Adam, W. Ed., Wiley-VCh, Weinheim, 2000, 139-156.

2. Muthusamy, S. and Krishnamurthi, J.
Heterocycles by Cycloadditions of Carbonyl Ylides Generated from Diazo Ketones
Topics in Hetereocyclic Chemistry, Heterocycles by Cycloadditions I
Hassner, A. Ed., Springer Verlag, 2008, 12, 147-192.


3. Hodgson, D. M; Labande, A. H.; Muthusamy, S.
Cycloadditions of carbonyl ylides derived from diazocarbonyl compounds
Organic Reactions, Wiley-VCH, 2012.


4. Mehta, G. and Muthusamy, S.
Tandem cyclization-cycloaddition reactions of rhodium generated carbenoids from -diazo carbonyl compounds
Tetrahedron, 2002, 58, 9477-9504.

Research Papers (15 Selective Articles)

1. Muthusamy, S.; Karikalan, T.; Gunanathan, C.; Suresh, E.
Rhodium(II) catalyzed intermolecular double C-alkylation: A method for the regiospecific synthesis of tetraindoles and indolophanes
Tetrahedron 2012, 68, 1595.

2. Muthusamy, S.; Karikalan, T.; Suresh, E.
Demonstration of 14-20 membered intramolecular carbonyl ylides: Diastereoselective synthesis of macrocycles incorporating spiro-indolooxiranes
Tetrahedron Lett. 2011, 52, 1934.

3. Muthusamy, S.; Srinivasan, P.
PPh3-mediated reactions of diazoimides in water: A facile synthesis of fused triazine derivatives
Tetrahedron Lett. 2009, 50, 1331.

4. Muthusamy, S.; Gnanaprakasam, B. Suresh, E.
New approach to the synthesis of macrocyclictetralactone via ring-closing metathesis using Grubbs' first generation catalyst
J. Org. Chem. 2007, 72, 1495.

5. Muthusamy, S.; Krishnamurthi, J.; Suresh, E.
Multicomponent reactions involving tricyclooxonium ylide intermediate: Diastereoselective synthesis of mono-and bisalkoxyoctahydro-1,4-benzodioxocin-6(5H)-one framework
J. Chem. Soc., Chem. Commun.2007, 861.

6. Muthusamy, S.; Krishnamurthi, J.; Babu,S. A.; Suresh, E.
Anonalous reactions of Rh2(OAc)4-generated transient carbonyl ylide: Chemoselective synthesis of epoxy-bridged tetrahydropyranone, oxepanone, oxocinone, and oxoninone ring systems
J. Org. Chem. 2007, 72, 1252.

7. Muthusamy, S.; Srinivasan, P.
Highly regio-, chemoselective ring opening of oxa-bridged piperidinones towards functionalized furanones and piperidines
Org. Lett. 2006,8, 5101.

8. Muthusamy, S.; Gnanaprakasam, B.; Suresh, E.
Desymmetrization of cyclic anhydrides using dihydroxy compounds: Selective synthesis of macrocyclic tetralactones
Org. Lett. 2006, 8, 1913.

9. Muthusamy, S.; Gnanaprakasam, B.; Suresh, E.
Regioselective nucleophilic addition to carbonyl ylide intermediates: A novel diastereoselective synthesis of cycloalkyl fused furan-3-ones
Org. lett. 2005, 7, 4577.

10. Muthusamy, S.; Krishnamurthi, J.; Nethaji, M.
Highly regio-, chemo- and diastereoselective synthesis of oxa-bridged spirocycles: A novel observation of reverse selectivity
J. Chem. Soc., Chem., Commun. 2005, 3862.

11. Muthusamy, S.; Krishnamurthi, J.; Suresh, E.
Highly regio- and stereoselective [3+2]-cycloaddition of carbonyl ylides with imines: A novel entry to oxa-bridged piperidinone ring systems
Synlett 2005, 3002.

12. Muthusamy, S.; Gunanathan, C.; Nethaji, M.
Diastereospecific tandem multicomponent reactions of diazoamides: A new access to spiro-furooxindoles
J. Org. Chem. 2004, 69, 5631.

13. Muthusamy, S.; Gunanathan, C.
Rh2(OAc)4-Catalyzed reactions of a-diazoimides: a simple and novel  synthesis of mono- and bis(2,3-fused perhydrooxazol-4-one) systems
J. Chem. Soc., Chem. Commun. 2003, 440-441.

14. Muthusamy, S.; Babu, S. A.; Gunanathan, C.; Ganguly, B.; Suresh, E.; Dastidar, P
Tandem cyclization-cycloaddition of rhodium carbenoids: Stereoselective synthesis of epoxy-bridged tetrahydropyranone ring systems
J. Org. Chem. 2002, 67, 8019

15. Muthusamy, S.; Gunanathan, C.; Babu, S. A.; Suresh, E.; Dastidar, P.
First example of regiospecific intermolecular C-H insertion reactions of cyclic rhodium carbenoids: Novel synthesis of 3,3'-indolyloxindoles
J. Chem. Soc., Chem. Commun. 2002, 824.